ozi

Dabere na ọkpụkpụ aza-BODIPY, NIR1001 na-agụnye otu ndị na-enye onyinye eletrọn (dịka, 4-N, N-diphenylaminophenyl) na ọnọdụ 2,6, na-eme usoro D-π-D symmetrical1. Nhazi a na-eme ka oghere HOMO-LUMO dị warara, na-agbanwe ọnụ ọgụgụ kachasị elu karịa 1000 nm ma na-akwalite nnyefe ụgwọ intramolecular (ICT). Na THF, NIR1001 na-egosipụta akụkụ obe nke foto abụọ kachasị elu (TPA) nke 37 GM, nkwalite okpukpu abụọ karịa usoro BODIPY ọdịnala. Oge ndụ ya nwere obi ụtọ nke steeti 1.2 ps na-enyere aka ntụgharị na-abụghị nke radieshọn nke ọma, na-eme ka ọ dabara maka ọgwụgwọ photodynamic (PDT).

Mgbakọ DFT na-ekpughe na usoro nnyefe ụgwọ nke NIR1001 sitere na π-electron delocalization n'etiti ndị na-enye onyinye na ndị na-anabata ya. Mgbanwe methoxy na-eme ka nnabata NIR dị na windo phototherapeutic (650-900 nm), na-emeziwanye nghọta1. E jiri ya tụnyere agba agba AF nke Mahadum Fudan, NIR1001 na-ejigide obere arọ molekụla (<500 Da) yana 40% fototability dị elu. Mgbanwe nke carboxylation na-eme ka solubility mmiri dịkwuo mma (cLogD = 1.2), na-ebelata mgbasa ozi na-abụghị nke akọwapụtara na usoro ndu.

3. Ngwa biomedical
Na bioimaging, hCG-conjugated probe hCG-NIR1001 na-enweta ihe onyonyo dị elu nke follicle ovarian na micro-metastases n'okpuru mkpali 808 nm. Site na ntinye omimi nke 3 cm na NIR-II, ọ na-eme nyocha NIR-I ugboro atọ, ebe ọ na-ebelata fluorescence ndabere site na 60%. N'ime ụdị mmerụ ahụ gbasara akụrụ òké, NIR1001 na-egosi nnabata 85% gbasara akụrụ, na-achọpụta mmebi ugboro isii ngwa ngwa karịa njikwa macromolecular.
Maka PDT, NIR1001 na-emepụta ụdị oxygen na-arụ ọrụ (ROS) na 0.85 μmol/J n'okpuru irradiation laser 1064 nm, na-ebute apoptosis cell tumor nke ọma. Liposome-encapsulated NIR1001 nanoparticles (NPs) na-akwakọba ugboro 7.2 karịa etuto ahụ karịa agba agba n'efu, na-ebelata mmetụta ndị ezubere iche.
4. Nlekọta ụlọ ọrụ na gburugburu ebe obibi
N'ime ngwa ụlọ ọrụ mmepụta ihe, etinyere NIR1001 n'ime Juhang Technology's SupNIR-1000 analyzer maka nhazi mkpụrụ osisi, ntule ịdị mma anụ na nhazi ụtaba. Na-arụ ọrụ na oke 900-1700 nm, ọ na-atụkwa ọdịnaya shuga, mmiri mmiri na ihe mgbochi pesticide n'otu oge n'ime sekọnd 30 na ± (50ppm + 5%) ziri ezi. N'ime ihe mmetụta CO2 akpaaka (ACDS-1001), NIR1001 na-enyere nlele oge anya na oge nzaghachi T90≤25s yana ogologo ndụ afọ 15.
Maka nchọpụta gburugburu ebe obibi, NIR1001-arụ ọrụ nyocha na-achọpụta ọla dị arọ na mmiri. Na pH 6.5-8.0, ike fluorescence na-ejikọta ọnụ na Hg²⁺ itinye uche (0.1-10 μM) na njedebe nchọpụta nke 0.05 μM, na-egosipụta ụzọ agba agba site n'ụkpụrụ abụọ nke ịdị ukwuu.
5. Nkà na ụzụ ọhụrụ na ịzụ ahịa
Ngwa Qingdao Topwellna-arụ ọrụ na-aga n'ihu iji mepụta NIR1001 na ịdị ọcha 99.5%, yana ikike 50 kg / batch. Iji microchannel reactors, a na-ebelata oge condensation nke Knoevenagel site na awa 12 ruo nkeji 30, na-ebelata oriri ike site na 60%. Usoro ISO 13485 nke asambodo NIR1001 na-achịkwa ahịa biomedical.